Top 10 most expensive prescription drugs in the US by price and by sales volume

On the heels of President Donald Trump’s Monday announcement of an enforcement bid that volition slash prescription cause prices successful the U.S., the spotlight is connected existent costs and however overmuch Americans could save.

The president’s bid calls for "most favored nations cause pricing" — which means "the lowest terms paid for a cause successful different developed countries, that is the terms that Americans volition pay," helium said.

"Some medicine cause and pharmaceutical prices volition beryllium reduced astir instantly by 50 to 80 to 90%," Trump said. 

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Katy Dubinsky, a New York pharmacist and laminitis and CEO of Vitalize, applauded the determination to trim medicine prices, noting that Trump’s order tackles a long-standing problem.

"But this volition not beryllium elemental to accomplish," she told Fox News Digital. 

Following President Trump’s announcement of an enforcement bid that volition slash medicine cause prices successful the U.S., the spotlight is connected existent costs and however overmuch Americans could save. (iStock)

"The enforcement bid doesn't trim costs immediately," she said. "It directs authorities agencies to commencement drafting the rules, which whitethorn instrumentality months."

Here are the 5 astir costly medicine drugs successful the U.S. by terms — followed by 5 by volume.

5 astir costly medicine drugs successful the US

Dubinsky elaborate immoderate of the astir costly medicine drugs successful the state contiguous and what conditions they treat.

1.  Lenmeldy (atidarsagene autotemcel) by Orchard Therapeutics – $4.25 million

This medicine is utilized to dainty metachromatic leukodystrophy (MLD), a uncommon familial upset that damages the nervous system, Dubinsky said. 

"It is fixed erstwhile and is expected to halt oregon dilatory down the illness successful young kids," she noted.

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2. Hemgenix (etranacogene dezaparvovec-drlb) by CSL Behring – $3.5 million

This medicine is prescribed for radical with hemophilia B, a bleeding disorder. 

"This one-time attraction helps the assemblage marque its ain clotting factor, truthful patients don’t request regular infusions," said Dubinsky.

3. Elevidys (delandistrogene moxeparvovec-rokl) by Sarepta Therapeutics – $3.2 million

This medicine medication, intended for young boys, treats Duchenne muscular dystrophy (DMD), a information that weakens muscles implicit time. 

"It aims to dilatory down however accelerated the illness progresses," Dubinsky said. 

The president’s bid calls for "most favored nations cause pricing," which means "the lowest terms paid for a cause successful different developed countries, that is the terms that Americans volition pay." (iStock)

4. Skysona (elivaldogene autotemcel) by Bluebird Bio – $3 million

"This medicine is utilized for cerebral adrenoleukodystrophy (CALD), a superior brain disease successful boys," said Dubinsky. "This therapy tries to dilatory the harm earlier symptoms get worse."

5. Zynteglo (betibeglogene autotemcel) by Bluebird Bio – $2.8 million

Zynteglo is for beta-thalassemia, a humor information that usually requires regular transfusions. 

"Some medicine cause and pharmaceutical prices volition beryllium reduced astir instantly by 50 to 80 to 90%."

"This gene therapy tin assistance patients marque steadfast reddish humor cells connected their ain and trim however often they request treatment," said Dubinsky.

Top 5 astir costly drugs by income volume

John Stanford, enforcement manager of Incubate, a Washington-based conjugation of early-stage life-science investors, shared his thoughts connected the apical 5 astir costly drugs by income volume.

"Typically, erstwhile the authorities is focused connected the astir costly drugs, they're focused connected the metric based connected income measurement alternatively than, for instance, a uncommon illness therapy with a precocious database terms but smaller diligent pool," helium told Fox News Digital.

"Often, officials are focused connected full cause spending by Medicare oregon different authorities programs."

"Typically, erstwhile the authorities is focused connected the astir costly drugs, they're focused connected the metric based connected income measurement alternatively than, for instance, a uncommon illness therapy with a precocious database terms but smaller diligent pool." (iStock)

1. Keytruda (pembrolizumab) by Merck — $25 cardinal gross (2023)

Keytruda is an immunotherapy medicine utilized to dainty a variety of cancers, including melanoma, non-small compartment lung cancer, liver crab and others.

"Keytruda has go Merck's crown jewel, helping the institution grow its crab attraction portfolio with much than 1,000 progressive objective trials," Stanford told Fox News Digital.

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2. Eliquis (apixaban) by Bristol Myers Squibb and Pfizer — $18.95 billion

Eliquis (apixaban) is an "anchor drug" for some BMS and Pfizer, according to Stanford.

Apixaban is prescribed to forestall the enactment of humor clots and to dainty heavy vein thrombosis and pulmonary embolism (a humor clot successful the lungs). 

3. Ozempic (semaglutide) by Novo Nordisk — $13.93 billion

Prescribed for type 2 diabetes, the semaglutide medicine Ozempic has go wide fashionable for its weight-loss effects and different wellness benefits.

Prescribed for benignant 2 diabetes, the semaglutide medicine Ozempic has go wide fashionable for its weight-loss effects and different wellness benefits. (REUTERS/Hollie Adams/File Photo)

"Ozempic's income are powering Novo Nordisk's broader foray into GLP-1s for obesity, heart disease and liver conditions — each areas with precocious improvement costs and uncertain technological outcomes," Stanford told Fox News Digital. 

"The wealth has gone toward scaling up accumulation to conscionable request for GLP-1s and debar proviso shortages."

4. Humira (AbbVie) — $14.4 cardinal (U.S. 2023 revenue)

"Humira has been 1 of the highest-grossing drugs successful history, generating implicit $200 cardinal during its exclusivity period," Stanford said.

The injectable medication, which contains the progressive constituent adalimumab, is utilized to dainty rheumatoid arthritis and different inflammatory conditions.

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5. Biktarvy by Gilead — $11.85 billion

Biktarvy is an HIV attraction that includes the 3 ingredients bictegravir, emtricitabine and tenofovir alafenamide.

"Biktarvy isn't conscionable a starring HIV treatment — it's the fiscal backbone for Gilead's determination into crab research," Stanford said.

Which drugs could beryllium affected?

Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, said vaccines and astir generic drugs would not apt beryllium changed by the enforcement order.

"Most vaccines that Americans instrumentality outgo little than a 100 dollars, portion generic drugs are often little than a dollar a pill," helium told Fox News Digital.

"From a patient’s perspective, the terms of aesculapian attraction successful the United States is unsustainable, and highly costly medicine is portion of that," 1 adept said. "However, the security strategy and the infirmary concern besides contribute." (iStock)

What would beryllium affected, Glanville predicted, are newer brand-name drugs inactive nether IP exclusivity, antibody therapies, cellular therapies, cistron therapies and personalized cancer vaccines.

"Some of these are excruciatingly costly — $100,000 to $500,000 for a attraction people for a patient. However, they are besides often the astir effectual treatments for definite cancers, autoimmune disorders oregon rare diseases."

The terms of innovation?

The pharmaceutical manufacture mightiness reason that lowering the prices connected these medicines volition effect successful a "dramatic simplification of investment" successful creating specified breakthroughs, said Glanville.

The manufacture whitethorn besides reason that these medicines yet go generic — astatine which constituent the prices drop, according to the expert.

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"From a patient’s perspective, the terms of medical care successful the United States is unsustainable, and highly costly medicine is portion of that," helium said. But "the security strategy and the infirmary concern besides contribute."

"If the prices of caller medicines are capped, past effort should beryllium made to trim the outgo of objective trials and cause GMP manufacturing. Otherwise, we volition suffer a batch of innovation."

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Greg Norman of Fox News Digital contributed reporting.